Method and apparatus for x-ray imaging with multiple source-detector pairs

ABSTRACT

The present invention pertains to an apparatus and method for medical imaging comprising rotating two X-ray source-detector pairs around an axis of rotation simultaneously to quickly acquire image data and form a computed tomography (CT) dataset. The sources can be configured to emit radiation from a plurality of discrete locations. The CT dataset can be utilized as a prior to reconstruct a three-dimensional image from subsequent bi-planar imaging with these source-detector pairs.

RELATED U.S. APPLICATION

This application is a continuation application claiming priority fromthe co-pending U.S. non-provisional patent application Ser. No.13/722,947, Attorney Docket Number TRT-14 entitled “METHOD AND APPARATUSFOR MULTIPLE X-RAY IMAGING APPLICATIONS,” with filing date Dec. 20,2012, which is hereby incorporated by reference in its entirety.

FIELD OF THE INVENTION

The present invention pertains to X-ray imaging systems. It particularlypertains to interventional X-ray imaging systems.

BACKGROUND

X-ray imaging procedures have not only become the standard for manydiagnostic applications in the medical field but have also seenincreasing use across a variety of surgical or interventionalapplications. Interventional procedures are less invasive alternativesto open surgery wherein implements are inserted through relatively smallincisions or natural orifices. Interventional procedures can beperformed under X-ray guidance by using X-ray fluoroscopy systems thatprovide real-time projection images. Increasingly interventionalspecialists are relying on 3-D images for intraoperative guidance andverification, such as images acquired by computed tomography (CT). Incontrast to clinical CT scanners these images are acquired at relativelyslow rotation speeds and typically have lower image quality thanclinical CT scans.

In some cases interventional specialists may use bi-planar fluoroscopysystems. In these systems two single-plane fluoroscopic systems canimage the patient from two different angular positions. Advantages ofusing such systems include the ability to provide the interventionalspecialist with additional spatial information and to reduce the amountof contrast agent that needs to be injected into the patient in order toview a contrast-highlighted internal feature from multiple angles.

Radiation exposure can be a concern with all X-ray imaging techniques.Concern has grown for fluoroscopy and CT in particular due to theirrelatively high levels of radiation exposure. While the benefits ofthese techniques can outweigh the risks of radiation exposure, provideimaging equipment that performs the imaging task at lower dose. Adrawback of some low-dose systems is a relatively small field of view,limiting use to cardiac applications. What is needed is an X-ray imagingsystem that can address the need for 3-D images during interventionalprocedures and is flexible enough for multiple interventional imagingapplications. What is further needed is a low dose imaging system forinterventional imaging applications.

SUMMARY

The present invention pertains to a method of medical imaging comprisingforming a computed tomography dataset by acquiring image data from twosource-detector pairs while rotating the pairs simultaneously throughnon-overlapping sets of angles around an axis of rotation. The sets ofangles can be at least 90 degrees each, and the rotations may becompleted in less than 3 seconds by a motor or other element. Additionalimage data can also be acquired from the source-detector pairs whilestationary and positioned at a predetermined angle relative to oneanother, and the computed tomography dataset can be used forregistration of this image data. The predetermined angle may space thesource-detector pairs between 80 and 100 degrees apart around an imagingvolume. Sources of the source-detector pairs may be configured to emitradiation from a plurality of discrete locations on their faces or maybe point sources. In the former case, the computed tomography datasetmay also be used as a prior, e.g. a Bayesian prior, for reconstructionof a three-dimensional image from the additional image data and forcorrection of image artifacts. A three-dimensional reconstruction fromthe image data acquired with the source-detector pairs in staticpositions may be completed with a maximum-likelihood maximization invoxel space, in and ordered-subset maximization framework, or with amaximum likelihood algorithm for transmission tomography.

The sources of source-detector pairs may be configured such that lessthan 10 cm exists between the pluralities of discrete emissive locationswhen the sources are positioned as near as possible. This configurationmay allow a relatively large field of view. The source-detector pairsmay also be configured to image a region of interest with higherexposure relative to other regions of the imaging volume.

These and other objects and advantages of the various embodiments of thepresent invention will be recognized by those of ordinary skill in theart after reading the following detailed description of the embodimentsthat are illustrated in the various drawing figures.

BRIEF DESCRIPTION OF THE DRAWINGS

The present invention is illustrated by way of example, and not by wayof limitation, in the figures of the accompanying drawings and in whichlike reference numerals refer to similar elements.

FIG. 1 is a diagram representing two source-detector pairs of anembodiment of the present invention.

FIG. 2 is a diagram illustrating a source-detector pair comprising amulti-focal spot source and small detector of one embodiment of thepresent invention.

FIG. 3 is a diagram showing an X-ray source and X-ray detector mountedon opposing ends of a medical C-arm in one embodiment of the presentinvention.

FIG. 4 is a diagram illustrating two source-detector pairs positioned ata minimum number of degrees possible for the given system geometry.

FIG. 5 is a diagram illustrating a field of view of a multi-focal spot,tomosynthetic imaging system.

FIG. 6 is a diagram illustrating a field of view of an embodiment of thepresent invention comprising two source-detector pairs.

FIG. 7 is a diagram illustrating two sources configured to minimize thenon-emissive surface existing between their adjacent edges in oneembodiment of the present invention.

FIG. 8 is a diagram illustrating a relationship between three modalitiesof an apparatus in one embodiment of the present invention.

FIG. 9 is a flowchart illustrating a number of manners in which two ormore modalities of an imaging apparatus may be utilized in conjunctionwith one another in an embodiment of the present invention.

DETAILED DESCRIPTION

Reference will now be made in detail to embodiments of the presentinvention, examples of which are illustrated in the accompanyingdrawings. While the invention will be described in conjunction withthese embodiments, it will be understood that they are not intended tolimit the invention to these embodiments. On the contrary, the inventionis intended to cover alternatives, modifications and equivalents, whichmay be included within the spirit and scope of the invention as definedby the appended claims. Furthermore, in the following detaileddescription of embodiments of the present invention, numerous specificdetails are set forth in order to provide a thorough understanding ofthe present invention. However, it will be recognized by one of ordinaryskill in the art that the present invention may be practiced withoutthese specific details. In other instances, well-known methods,procedures, components, and circuits have not been described in detailas not to unnecessarily obscure aspects of the embodiments of thepresent invention.

FIG. 1 is a diagram representing two source-detector pairs of anembodiment of the present invention. Embodiments of the presentinvention may feature two or three X-ray sources and two or three X-raydetectors. In FIG. 1 a first source 14 and a first detector 16 arepositioned such that the face of first source 14 and the face of firstdetector 16 may be parallel and separated by a distance long enough toaccommodate a patient or subject for imaging. A second source 15 and asecond detector 17 may be similarly positioned relative to one another;the face of second source 15 may be parallel to the face of seconddetector 17 with a distance long enough to accommodate imaging subjectsmaintained between them. A first axis 11 has been drawn connecting thecenters of the faces of first source 14 and first detector 16, and asecond axis 12 has been drawn connecting the centers of the faces ofsecond source 15 and second detector 17. These axes may be physical,e.g. beams or other supports, or non-physical, e.g. maintained bymaintaining the spatial relationship of a source and detector relativeto one another. For example, in embodiments of the present inventionmedical C-arms, U-shaped arms, O-arms, physical axes of other shapes,tracks along which source and detector motion can be confined, closedgantries, or any other mechanical structure may be used to maintain thefixed distances between, orientations of, and rotations about anisocenter by two source-detector pairs.

In some embodiments of the present invention, the distance maintainedbetween source and detector in source-detector pairs can be 3, 4, 5, 6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 inches, or anynon-integer number of inches between these enumerated values. Theseembodiments of the present invention may be particularly useful for theimaging of extremities, including but not limited to podiatric, dental,and similar imaging applications. In some embodiments of the presentinvention, the distance maintained between source and detector insource-detector pairs can be between 20 inches and 120 inches, 30 inchesand 100 inches, or 40 inches and 70 inches, inclusive, and any otherinteger or non-integer number of inches within the enumerated ranges.For example, the distance may be 30, 31, 32, 33, 34, 35, 36, 37, 38, 39,40, 41, 42, 43, 44, 46, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, or 56inches, or any non-integer number of inches between the enumeratedvalues.

A point of overlap 18 between first axis 11 and second axis 12 maycorrespond to an isocenter of the system, e.g. a point at which an X-raybeam traveling from the center of the face of first source 14 to thecenter of the face of first detector 16 would intersect an X-ray beamtraveling from the center of the face of second source 15 to the centerof the face of second detector 17. While angle 13 between first axis 11and second axis 12, relating to the separation between the two sourcesor between the two detectors, may change, the isocenter of the systemcan remain fixed in space at point of overlap 18.

In one embodiment of the present invention, first source 14 and secondsource 15 may be point sources, wherein X-rays are emitted from a singlediscrete point on the face of the source. A point source may be an X-raytube or any other means of emitting X-ray radiation from a smalldiscrete point. In this embodiment, first detector 16 and seconddetector 17 may be any type of X-ray detecting sensors, including butnot limited to flat-panel detectors or image intensifier systems.

In another embodiment of the present invention, first source 14 andsecond source 15 may be multi-focal spot sources, wherein X-rays can beemitted from a plurality of discrete locations of the face of thesource. A multi-focal spot source may be array of carbon nanotubes, ascanning beam source, a scanning laser source, an array of singlecathode emitters, or any other source capable of emitting radiation froma plurality of discrete locations on its face. First detector 16 andsecond detector 17 may be any type of X-ray detecting sensor includingbut not limited to fast photon-counting detectors. One example of amulti-focal spot source and photon-counting detector combination thatmay be utilized in this embodiment of the present invention is disclosedin U.S. Pat. No. 5,729,584 entitled “Scanning Beam X-ray Imaging System”and hereby incorporated by reference.

The faces of sources and detectors in embodiments of the presentinvention may also be circular, square, polygonal, rectangular,trapezoidal, triangular, or any other shape. Embodiments of the presentinvention utilizing multi-focal spot sources may comprise source facesof diameters or widths ranging from 1″ to 5″, 5″ to 10″, 10″ to 15″, or15″ to 20″, inclusive, or any other integer or non-integer number ofinches within the enumerated ranges. Embodiments of the presentinvention utilizing pixelated detectors in conjunction with multi-focalspot sources may comprise detectors of diameters or widths ranging from1 to 2 cm, 2 to 3 cm, 3 to 4 cm, 4 to 5 cm, 5 to 6 cm, 6 to 7 cm, 7 to 8cm, 8 to 9 cm, 9 to 10 cm, 10 to 11 cm, 11 to 12 cm, 12 to 13 cm, 13 to14 cm, 14 to 15 cm, 15 to 16 cm, 16 to 17 cm, 17 to 18 cm, 18 to 19 cm,or 19 to 20 cm, inclusive, or any non-integer number of centimetersbetween the enumerated values.

Embodiments of the present invention utilizing point X-ray sources mayemit X-rays from an emissive point or spot having a diameter or width of0.1 mm to 5 mm, inclusive. Emissive points or spots may further have awidth, diameter, or full-width at half maximum between 0.1 mm and 0.5mm, 0.5 mm and 1.0 mm, 1.0 mm and 2.0 mm, 2.0 mm and 3.0 mm, 3.0 mm and5.0 mm, or any other integer or non-integer number of millimeters withinthe enumerated ranges. Diameters or widths may also be larger than 5.0mm, though image resolution may degrade with increasing focal spot size.Embodiments of the present invention utilizing point sources maycomprise detectors of widths or diameters of 0 to 10 cm, 10 to 20 cm, 20to 30 cm, 30 to 40 cm, 40 to 50 cm, or 50 to 60 cm, inclusive, or anyother integer or non-integer number of centimeters within the enumeratedranges. For example, detectors may have widths or diameters of 15, 16,17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,or 35 cm, inclusive, or any non-integer number of centimeters betweenthe enumerated values. It is possible that detector widths or diametersmay be greater than 60 cm for some applications.

In embodiments of the present invention comprising multi-focal spotsource, each source-detector pair may provide tomosynthetic image datadue to the plurality of focal spots on the source face; a specific planeor multiple planes within the field of view of a given source-detectorpair may be reconstructed. System comprising multi-focal spot sourcescan also demonstrate superior contrast-to-noise and lower patientexposure at a given level of image quality compared to point-source, orshadowgraph, systems, as detectors can be smaller and collect lessscattered radiation.

FIG. 2 is a diagram illustrating a source-detector pair comprising amulti-focal spot source and small detector of one embodiment of thepresent invention. Source 31 can project beams of radiation from aplurality of discrete locations towards a detector. For example, a beam34 can be emitted from a discrete focal spot 33 and configured toilluminate detector 35.

In one embodiment of the present invention, the distances andorientations of two X-ray source-detector pairs may be maintained by thesources and detectors being mounted on two medical C-arms. FIG. 3 is adiagram showing an X-ray source and X-ray detector mounted on opposingends of a medical C-arm in one embodiment of the present invention. Asecond C-arm holding a second source-detector pair may also be affixedat joint 22. Rotation of the C-arm 21 may occur around a rotation axisthrough a joint 22 and an isocenter 19 of the system; in the view ofFIG. 3, first source 14 and first detector 16 may be rotated into or outof the page. Both C-arms can rotate around a common axis of rotationthrough a shared isocenter.

An isocenter may or may not be located at the midpoint between a sourceand detector in a source-detector pair. It may be desirable that a humanpatient can be positioned at the isocenter of the system so thatrotations occur around the patient and the targeted patient volumeremains in focus even if the angle between the source-detector pairschanges. In point-source systems imaging performance may be optimized bypositioning a patient nearer to the detector than to the source.Therefore, in an embodiment of the present invention comprisingpoint-source systems, source-detector pairs may be connected to oneanother in a manner that creates a system isocenter closer to thedetectors than to the sources. For example, with reference again to FIG.1, the system may be configures such that point of overlap 18 is nearerto first detector 16 and second detector 17 than first source 14 andsecond source 15 along first axis 11 and second axis 12, respectively.In tomosynthetic imaging systems, imaging performance may be optimizedby positioning a patient nearer to the source than the detector. Anembodiment of the present invention comprising tomosynthetic systems maybe configured such that a system isocenter is closer to the sources thanthe detectors of two source-detector pairs.

A visualization of an offset or non-centered isocenter may be a pair ofscissors. A pair of scissors is made up of two pieces, each piecetypically being a blade with a handle. The handle is typically shorterthan the blade, but a joint is usually placed between the handle and theblade, not at the actual midpoint of a piece. Blades and handles rotatearound the joint, or isocenter, of the scissors despite differinglengths on either side of the joint.

The curved geometry of C-arms may permit the placement of an area orvolume of a patient to be imaged at the isocenter of two source-detectorpairs in embodiments of the present invention. A patient may bepositioned on a bed or table or otherwise secured within the crook or“C” of the C-arms while imaging occurs. Furthermore, an apparatus towhich the two C-arms are affixed may rotate the C-arms around other axesto widen the range of possible patient positions. For example, withreference to FIG. 3, joint 22 may be moved vertically or along a curvedtrack.

The rotation of source-detector pairs around an isocenter, e.g. thechange in an angle between the source-detector pairs, may beelectronically controllable. For example, an embodiment of the presentinvention may include an electronically controlled mechanical motor, setof motors, actuators, or other means of rotating the source-detectorpairs. The means of rotation may be coupled to an electronic input unitallowing a user to select rotation parameters to be implemented duringimaging. Optional input values may also include frame rate, e.g. thefrequency at which images are captured, total number of degrees to berotated, or other imaging-related parameters. Alternatively, anembodiment may be configured to convert a user-selected end-result, e.g.a number of images of a given level of quality taken at specific angularintervals, into appropriate operating parameters, e.g. angular speed,frame rate, etc., required to achieve said end-result. The calculationof operating parameters may account for system-specific capabilities;information regarding the speed at which the imaging system can collectsufficient data for image reconstruction at a given level of quality,the speeds to which axes can be safely accelerated or decelerated, theangles through which axes can rotate without contact between sources anddetectors, and so forth may be included in the determination ofoperating parameters.

Embodiments of the present invention may be used for at least threedifferent imaging procedures: computed tomography (CT), bi-planarimaging, and fluoroscopy. Physicians within an operating room,catheterization lab (“cath lab”), or other facility may wish to performone, two, or three of these imaging procedures for pre-operativediagnosis, intraoperative guidance, post-operative verification, andother purposes. Embodiments of the present invention with these threedifferent modalities can prove space- and cost-efficient and may alsoincur speed and image quality benefits compared to single-modalitysystems.

In a computed axial tomography (CAT) scan a patient may be positioned ona table and slid through an enclosed, circular gantry. An X-ray sourceand arc of X-ray detectors may be positioned opposite one another insidethe gantry and rotated at a high speed to acquire images from a seriesof different angles or views. A comprehensive three-dimensional image ofthe imaging volume can be formed by reconstructing the series of viewsand can be used for identification of cancers, tumors, infarctions,fractures, and other internal conditions. This type of three-dimensionalimage may be desirable during a medical procedure, for example toaccurately position an implement that has been inserted into thepatient, e.g. an ablative device or catheter, or to ensure that amedical condition has been sufficiently corrected, e.g. cancer removedor infarction cleared, before completing the surgery and closingincisions. However, during an interventional or surgical procedurepositioning a patient for a conventional CAT scan may be difficult orimpossible. A CT dataset or image may instead be acquired by rotating aC-arm on opposing ends of which are mounted an X-ray source and an X-raydetector such that the X-ray source and detector can rotate around thepatient, sliding an O-arm around the patient within which source anddetector rotate, or by similarly lower-profile methods.

To accurately reconstruct a three-dimensional representation of atargeted volume, images may be taken through at least 180 degrees, plussome number of degrees that account for beam properties, around theimaging volume. An intraoperative CT imaging system may be designed toacquire images through the 180 plus degrees as quickly as possiblebecause patient motion between frames, even from a patient's breathingor heartbeat, can introduce motion blurring into individual frames orthe final three-dimensional reconstruction. Imaging speed may also beimportant as patients may be involved in a time-sensitive medicalprocedure or otherwise ill or injured. The maximum rotational speedsafely achievable in intraoperative CT may be significantly lower thanin a CAT scan.

In one embodiment of the present invention, two X-ray source-detectorpairs may be rotated in a manner such that one source-detector pair cansweep out a number of degrees while the other source-detector pairsweeps out the rest of the degrees necessary to construct athree-dimensional CT image. In this embodiment, the number of viewsrequired for the CT reconstruction can be collected in half the time itwould have taken a single axis rotating at the same speed to collect theviews.

Source-detector pairs may be rotated through any total number of degreespossibly ranging from one to 360 degrees. Reconstructed CT image qualitymay be enhanced for numbers of degrees greater than 180. Someembodiments of the present invention may rotate source-detector pairsthrough a total number of degrees between 180 and 185, 185 and 190, 190and 200, 200 and 205, 205 and 210, or 210 and 215 degrees, inclusive.Some embodiments of the present invention may rotate source-detectorpairs through a total number of degrees between 215 and 230, 230 and245, 245 and 260, 260 and 275, 275 and 290, 290 and 305, or 305 and 320inclusive. Some embodiments of the present invention may rotatesource-detector pairs through a total number of degrees between 320 and325, 325 and 330, 330 and 335, 335 and 340, 345 and 350, or 355 and 360,inclusive. Source-detector pairs may be initially positioned with anyangle between them allowing the predetermined amount of rotation tooccur and may be rotated in the same direction or in opposingdirections.

The time taken for a single axis carrying a source and detector torotate through and obtain images at a given set of degrees can belimited by patient safety concerns. Currently, fast C-arm CT scans maytake approximately four to six seconds. This speed may increase in thefuture. Embodiments of the present invention can cut the minimum timerequired to complete an intraoperative CT in half. For example, if fourto six seconds is assumed as a reference time for intraoperative CT witha single source-detector pair, then an intraoperative CT scan using twosource-detector pairs may take only 2 to 3 seconds, or less than 3seconds.

In one embodiment of the present invention, source-detector pairscomprising point-source imaging systems are used to acquire a CT datasetin less than 3 seconds, or half the time that would be required toacquire the dataset with a single source-detector pair. Image data canbe acquired at a predetermined number of angles, e.g. views, as thesource-detector pairs are rotated, and reconstruction of athree-dimensional image may be accomplished using standard cone-beamreconstruction, multiplanar reconstruction, standard filtered backprojection, maximum-likelihood algorithm for transmission tomography,ordered subset expectation maximization, or any other iterative ornon-iterative CT reconstruction method or combination of methods.

In another embodiment of the present invention, source-detector pairscomprising multi-focal spot sources are used for acquisition of a CTdataset. The low-dose advantages of multi-focal spot source, e.g.tomosynthetic, systems may be particularly desirable in CT applicationsas concerns exist regarding the amount of radiation incurred by patientswhile undergoing CT, a large number of high-quality images providing themost accurate three-dimensional reconstruction, and its effect on theprobability of cancer development. Image data collected as thesource-detector pairs rotate may be used to generate image planes usingshift-and-add reconstruction or other techniques as described in U.S.Pat. No. 6,178,223 entitled “Image reconstruction method and apparatus,”hereby incorporated by reference. Reconstruction of a three-dimensionalimage may be accomplished using maximum likelihood expectationmaximization (MLEM); Fourier re-binning with John's equation (FORE-J),which can re-sort image data acquired with a multi-focal spot source toresemble data acquired with a point source; maximum-likelihood algorithmfor transmission tomography (ML-TR); ordered subset expectationmaximization (OSEM); or any other iterative or non-iterativethree-dimensional reconstruction algorithms or combinations thereof.

In one embodiment of the present invention, datasets acquired during afast C-arm CT scan are reconstructed using an iterative algorithmutilizing the maximum-likelihood algorithm for transmission tomography(ML-TR) as described by De Man et. al. [cite] ML-TR seeks to find a setof linear attenuation coefficients {μ_(i)}_(j=1) ^(J) that maximizes thelog-likelihood for a set of measurements {y_(i)}_(i=1) ^(I).

L=Σ _(i=1) ^(I)(y _(i)·ln(ŷ _(i))−ŷ _(i))

where i denotes a given projection line, j a given pixel, and ŷ theexpected number of photons detected along projection line i given thecurrent reconstruction {μ_(i)}. It can be shown that

$\mu_{j}^{n + 1} = {\mu_{j}^{n} + \frac{\sum\limits_{i = 1}^{I}{l_{ij} \cdot ( {{\hat{y}}_{i} - y_{i}} )}}{\sum\limits_{i = 1}^{I}{l_{ij} \cdot {\lbrack {\sum\limits_{h = 1}^{J}l_{ih}} \rbrack.{\hat{y}}_{i}}}}}$

maximizes this log-likelihood. The expected number of photons ŷ along agiven projection line can be calculated as

${\hat{y}}_{i} = {b_{i} \cdot {\exp ( {- {\sum\limits_{j = 1}^{J}{l_{ij}\mu_{j}}}} )}}$

where the factor b_(i) can be determined by acquiring images from thesource-detector pairs with no imaging volume present.

In a further embodiment, the ML-TR algorithm can be implemented in anordered-subset maximization (OSEM) framework. This embodiment mayimprove the computational speed of reconstruction. A principle of OSEMis to perform iterations only for a small subset of angular samples,which may be widely spaced over the angular range. Subsequent iterationscan then be performed on different subsets until all angles have beenused and one complete iteration has been performed.

In this embodiment of the present invention, the number of subsetsutilized may range from one to the number of views acquired, e.g. thenumber of angles at which an image dataset is acquired, inclusive. Thenumber of subsets utilized may also be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25. The number ofviews within a subset may be any number of views between two views andthe number of views acquired, inclusive. The number of views in a subsetmay also be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or any othernumber of views. For example, in one embodiment of the presentinvention, each of two source-detector pairs can be rotated through 180degrees and acquire image data, e.g. a view, every 4 degrees such that atotal of 90 views over 360 degrees are acquired. A reconstructionalgorithm implementing ML-TR in an OSEM framework could then utilize,for example, fifteen subsets, each subset comprising six views, andpossibly be run for ten complete iterations.

Embodiments of the present invention may also be used for imagingwithout rotation of the source-detector pairs, in which case connectiveaxes of the pairs may be fixed at a given angle relative to one anotherduring the imaging process. For bi-planar imaging, the angle between thetwo source-detector pairs of an embodiment of the present invention maybe fixed at any integer or non-integer number of degrees between zeroand 180. A near-zero minimum angle and near-180 maximum angle betweensource-detector pairs in embodiments of the present invention may bedetermined by the angles at which adjacent edges of the two sources ortwo detectors come into contact. For example, if the source-detectorpairs are multi-focal spot, tomosynthetic systems, angles may beconstrained by the edges of the two source faces coming into contactwith one another, the sources being the relatively larger elements ofsource-detector pairs. If the source-detector pairs are point X-raysource imaging system, angles may be constrained by the edges of the twodetector faces coming into contact.

The angle between the two source-detector pairs of embodiments of thepresent invention may be a number of degrees between 0 and 10, 10 and20, 20 and 30, 30 and 40, 40 and 50, 50 and 60, 60 and 70, 70 and 80, 80and 90, 90 and 100, 100 and 110, 110 and 120, 120 and 130, 130 and 140,140 and 150, 150 and 160, 160 and 170, or 170 and 180, inclusive, or anyother integer or non-integer number of degrees between the enumeratedvalues.

Bi-planar X-ray imaging may be particularly useful for procedures inwhich a contrast agent may be inserted into a patient to highlight veinsor other features that are not intrinsically opaque to X-ray radiation.It may be desirable to limit the amount of contrast agent injected intoa patient as contrast agents have been known in some cases to causeallergic reactions and even kidney failure. When more than oneperspective of a feature highlighted by a contrast agent may be usefulto a physician, two X-ray imaging systems positioned at different anglesaround the patient may be utilized for bi-planar image acquisition aftera single dose of contrast agent has been administered. Acquiring twoviews simultaneously can spare the additional dose of contrast agentwhich may be administered if time were taken to move an X-ray systemfrom one angle to another.

In one embodiment of the present invention, a novel bi-planar imagingsystem may comprise two multi-focal spot, tomosynthetic imaging systems.Multiple planes between a source and detector can be reconstructed fromthe data acquired by a single system, and a three-dimensional image orvideo may be constructed using the data acquired by both systems.Acquisition of a three-dimensional image in this fashion may providesignificantly less radiation exposure to the patient compared tocollecting projection images through 180 degrees or more around thepatient, e.g. compared to computed tomography; this embodiment may allowa surgeon to acquire three-dimensional images frequently during aprocedure without concern of excessive radiation dose. Furthermore, thisembodiment may enable real-time, e.g. video, imaging, whereas even CATscans may not acquire data fast enough to generate real-timethree-dimensional images.

Reconstruction of a three-dimensional image from two tomosyntheticimages in embodiments of the present invention may be accomplished usingMLEM, ML-TR, or any other reconstruction algorithm in voxel space. Avoxel may be considered the three-dimensional equivalent of a pixel; ifa pixel is considered a square area in two-dimensional space, a voxelwould be a cubic volume in three-dimensional space. In one embodiment ofthe present invention, an ML-TR algorithm in an OSEM framework may beutilized to reconstruct a three-dimensional image from two bi-planarimages. For example, one subset comprising two views may be utilized.

Three-dimensional reconstruction from two tomosynthetic images may beoptimized when the images are acquired with source-detector pairspositioned when the angle between source-detector pairs is between 60and 120 degrees, 70 and 110 degrees, or 80 and 100 degrees, inclusive,e.g. nearly perpendicular to one another. However, three-dimensionalreconstruction from two tomosynthetic images in this embodiment of thepresent invention may also be accomplished for other angles ofseparation. For example, angles less than 60 degrees may be optimal ifthe spatial frequency of an imaging volume is significantly higher inone dimension than in another, e.g. if details of an imaging volumeviewable from one direction are much finer than those in a perpendicularview.

In embodiments of the present invention, the axes of two source-detectorpairs may also be fixed at the smallest angle possible given thegeometry of the system, e.g. at a near-zero minimum number of degrees aspreviously discussed. FIG. 4 is a diagram illustrating an embodiment ofthe present invention with two source-detector pairs positioned at theminimum number of degrees given the source and detector geometry. Facesof two multi-focal spot sources of tomosynthetic source-detector pairsmay be in an angled configuration 63. Reconstruction algorithms canaccount for the imaging geometry created by angled configuration 63 andproduce images similar to those that would have been acquired by asingle, extended flat detector. This correction can be accomplishedusing a mask or any other method of correcting for known imagedistortions. For example, an appropriate assignment of the signals frompixels of detectors 61 into an image plane can be determinedanalytically or experimentally and can account for the sampling effectsof angled configuration 63.

Flat configuration 64 may represent the area that would be subtended bythe two multi-focal spot sources shown in angled configuration 63 ifthey were instead positioned adjacently in the same plane. OutermostX-ray paths 62 between detectors 61 and angled configuration 63 are alsoshown. X-ray paths 62 are extended past angled configuration 63 into theplane of flat configuration 64 to represent the boundaries of the flatsource that is “simulated” by two sources in angled configuration 63. Itcan be seen that a simulated flat detector can actually be wider thanthe source area created by flat configuration 64. The size of amulti-focal spot source may be related to the field of view availablefrom an imaging system; the angled configuration that may be createdwhen two source-detector pairs are positioned at a smallest possibleangle in embodiments of the present invention may achieve a larger fieldof view than if a flat source of equivalent surface area were used.

The field of view (FOV) of an imaging system may refer to the dimensionsof the region that can be imaged by the system. The FOV of an imagingsystem may in large part be determined by imaging geometry of thesystem, including but not limited to the size of one or more of itscomponents, e.g. source or detector, and the distances maintainedbetween the source, detector, and subject during imaging. Despitelow-dose and other advantages, tomosynthetic imaging systems utilizing amulti-focal spot source have seen somewhat limited application,primarily being used for cardiac procedure and related imaging, due totheir relatively small fields of view. One embodiment of the presentinvention comprises two tomosynthetic imaging systems, positioned at anear-zero minimum number of degrees. This embodiment may provide afield-of-view large enough for a wider range of applications, includingfluoroscopy and interventional procedures on larger tissues and organsof the human body, e.g. cranial, gastrointestinal, or other procedures.

FIG. 5 is a diagram illustrating a field of view of a multi-focal spot,tomosynthetic imaging system. A possible imaging volume 159 is indicatedbetween large source 59 and small detector 151. It can be seen that thewidest field of view 158 may be on the source side of the imagingvolume. FIG. 6 is a diagram illustrating a field of view of anembodiment of the present invention comprising two multi-focal spotsource-detector pairs. First small detector 51 and second small detector52 can be illuminated by first large source 53 and second large source54, respectively. A possible imaging volume 150 of this embodiment maybe larger than imaging volume 159 available from a singlesource-detector pair. Particularly, a maximum field of view 149 may besignificantly wider than field of view 158 available from the singlesource-detector pair. This embodiment may provide a field of viewsuitable for a broader range of clinical applications than existingtomosynthetic imaging systems.

It can also be seen in FIG. 6 that imaging volume 150 may have regionalvariations in X-ray flux. A central region of imaging volume 150 may beimaged by both source-detector pairs, whereas outer regions of theimaging volume may be imaged by a single source-detector pair. As thecentral region may receive twice the amount of X-ray flux relative toouter regions of the imaging volume, reconstructed images may displayhigher contrast-to-noise ratios and less out-of-plane blurring in thearea imaged near the center of the imaging volume relative to the outeredges of the imaging volume.

Differing degrees of image quality within a single X-ray image can bedesirable as a physician may wish to view a small region of interest(ROI), such as a heart during a cardiac procedure, with veryhigh-quality images, e.g. good contrast-to-noise, while generallymonitoring the surrounding area. Since prolonged X-ray exposure can haveadverse health effects, it can be beneficial to use a lower amount ofX-ray flux to image areas outside of the ROI. Source-to-detectordistance, source size, detector size, or other parameters of imaginggeometry may be configured to create a central region, e.g. regionimaged by both source-detector pairs, that is the size of a probableregion of interest for a given application or range of applications.Alternatively, a system may be designed such that the region receivingflux from both X-ray sources is large enough to encompass the full widthof a human body. In this embodiment, a patient may be positioned suchthat an entire plane or planes of interest can be imaged with highcontrast-to-noise and low out-of-plane blurring.

Fields of view of embodiments of the present invention may be circular,square, polygonal, rectangular, trapezoidal, triangular, or any othershape, e.g. as determined by source and detector geometry. A field ofview may have a maximum diameter or width of 5 to 10 cm, 10 to 15 cm, 15to 20 cm, 20 to 25 cm, 25 to 30 cm, 30 to 35 cm, 35 to 40 cm, 40 to 45cm, or 45 to 50 cm, inclusive, or any integer or non-integer number ofcentimeters within these enumerated values. For example, a field of viewmay have a diameter of 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 cm,inclusive, or any non-integer between these enumerated values. For someapplications, a field of view may have a diameter or width of less than5 cm or greater than 40 cm.

For example, one embodiment of the present invention comprises twotomosynthetic source-detector pairs each having an individual field ofview with a diameter of approximately 20 cm and a total field of viewwhen positioned at a minimum possible angle of approximately 35 cm.Source faces in this embodiment may be circular and may have a diameterof 10″. Detector faces may be rectangular and may be 10 cm by 5 cm.

Since each multi-focal spot source in embodiments of the presentinvention may have an amount of non-emissive, e.g. dead, space along theedges of its face due to source housing, connections to the targetmaterial, or other support structures, a gap in emissive locations mayexist between the two source faces when positioned in the configurationof FIG. 6. This gap may affect the size or shape of the imaging volumeor maximum field of view. Depending on the positioning of a patientrelative to the source for a give application, the effect on the imagingvolume may or may not be detrimental.

FIG. 7 is a diagram illustrating two multi-focal spot sources of oneembodiment of the present invention configured to minimize the distancefrom emissive locations on one source to those on the other when thesources are positioned adjacently, e.g. with a minimum angle betweensource-detector pairs. The focal spot pattern across the faces of twosources in this embodiment may resemble the pattern of focal spots on asingle, large-area multi-focal spot when they are placed in contactadjacently. For example, two scanning-beam sources may be fabricatedwith emissive target screens extending very close to edges of the sourcefaces, reducing dead area along edges at which two source faces meet.Other types of source pairs may be configured to minimize a gap in theemissive surface, including a pair of nanotube arrays or any other pairof sources with little to no dead space along two adjacent edges. Inthese embodiments, a gap may be 2 cm, 3 cm, 4 cm, 5 cm, 6 cm, 7 cm, 8cm, 9 cm, 10 cm, or a non-integer number of centimeters between theseenumerated values. A gap may also be between 10 and 15 cm, 15 and 20 cm,25 and 30 cm, 30 and 35 cm, 35 and 40 cm, 40 and 45 cm, or 45 and 50 cm,inclusive.

In one embodiment of the present invention, two scanning beam sourcesconfigured with minimal non-emissive area along adjacent edges and twophoton-counting element-array detectors may be attached to two C-arms,e.g. such that each C-arm has a source on one end and a photon-countingdetector on the opposing end. The two C-arms may be connected to oneanother by a joint aligned with an isocenter of the two source-detectorpairs. Either the joint or another point on either C-arm may beconnected to a support structure.

FIG. 8 is a diagram illustrating a relationship between aspects of threemodalities of an embodiment of the present invention. In the embodimentof FIG. 8, an apparatus modality may be selected, as indicated bydecision block 91. The modality may be for example a computed tomographymodality 92, an extended-FOV fluoroscopy modality 93, or a bi-planarimaging modality 94. In one embodiment, in computed tomography modality92 the apparatus may allow election in a decision block 95 to either setoperating parameters, e.g. rotation speed, frame rate, etc. in option97, or image specifications, e.g. final image resolution, in option 96.Operating parameters may be calculated in step 98 if a user selectsoption 96. Alternatively, a system may only provide option 96 or onlyprovide option 97 under computed tomography modality 95. The system canimplement the operating parameters from option 97 or step 98, acquiringimages while rotating two or more source-detector pairs around anisocenter, as in step 99. Any type of CT reconstruction method can beutilized to generate a three-dimensional image in step 100.

For extended-FOV fluoroscopy modality 93 source-detector pairs of thesystem may be aligned at a near-zero minimum angle, e.g. with sources ordetectors in contact adjacently. In step 101 a single set of image datamay be acquired in this configuration or image data may be continuouslyacquired. If predetermined artifacts of system geometry are present inacquired images, they may be corrected in step 102 prior to displayingan image or video in step 103. Alternatively, a single source-detectorpair may be utilized in extended-FOV fluoroscopy modality 93 if thefield of view provided by the single source-detector pair is sufficientfor a given application.

For bi-planar imaging modality 94 source-detector pairs may bepositioned at any angle relative to one another in step 105. An image,images, or video can be displayed in step 106. If the apparatuscomprises tomosynthetic source-detector pairs, then a three-dimensionalimage or video may also be reconstructed from two bi-planar data sets instep 107.

Other embodiments of the present invention utilize multiple modalitiesof an imaging system capable of at least three different imagingprocedures in conjunction with one another, potentially to optimize theaccuracy or registration of one or more of these modalities.

Registration may refer to the determination of a spatial relationshipbetween multiple views, e.g. image data sets, of the same object orimaging volume, for example by selecting a reference data set andtransforming coordinates of any other data sets into the coordinates ofthe reference data set. Accurate image registration can properly combineor overlay multiple data sets. Registration can be achieved by featurerecognition, intensity mapping, or other methods relating data sets tothe reference data set.

In one embodiment of the present invention, a three-dimensional imagecan be reconstructed from two bi-planar images acquired with multi-focalspot sources. In this embodiment, a CT data set can also be acquiredwith the same source-detector pairs used for bi-planar imaging. A lackof relative motion between the patient and imaging system can beachieved between the CT scan and bi-planar image acquisition. The CTdata set can be used as a reference data set for registration of the twobi-planar images. A CT scan may also be utilized for registration ofimages acquired via other modalities of the imaging system, e.g.fluoroscopy, and with an imaging system comprising point sources ratherthan multi-focal spot sources.

In other embodiments of the present invention, imaging artifacts frominsufficient data can be alleviated with a CT scan taken with little orno motion between the patient and imaging system during the transitionfrom a CT to another imaging modality. Data from a preliminary orsecondary CT scan can be used as a prior, e.g. a Bayesian prior, forreconstruction. Alternatively, another method of improvingreconstructions with an additional data set may be used. In one suchembodiment, two bi-planar tomosynthetic data sets can be reconstructedto form a three-dimensional image using MLEM, ML-TR, OSEM, ML-TR in anOSEM framework, or any other iterative or non-iterative reconstructionalgorithm. The value of a given pixel or voxel from the preliminary CTdataset can be incorporated as a constraint, factor, or other term whendetermining probable pixel or voxel values via likelihood maximizationor another method of the reconstruction algorithm.

Interventional procedures can often be planned based on an image orseries from a preliminary CAT scan, which, for example, shows a tumor orother malignancy and surrounding internal features. This preliminary CATscan may have been completed relatively long before, e.g. days, weeks,or months before, the interventional procedure. Internal features of apatient can change between the time at which the CAT scan completed andthe time of the procedure, e.g. from weight loss or malignancy growth.

In one embodiment of the present invention, a CT modality of an imagingsystem comprising a set of source-detector pairs may be utilizeddirectly before an interventional procedure. The interventionalprocedure may be guided by a fluoroscopy modality of the same imagingsystem. This embodiment allows a CT scan to be quickly completed beforean interventional procedure without moving the patient or imagingsystem. A lack of relative motion between the patient and apparatus canresult in this preliminary CT scan providing absolute locations orcoordinates of internal features within the patient where they may beduring the procedure.

In another embodiment of the present invention, an interventionalprocedure requiring some amount of three-dimensional information in alocalized region, e.g. in the cardiac region for placement of anablative device, can be completed using bi-planar imaging. A fast CTscan can be taken prior to bi-planar imaging, and the third-dimensioncoordinate of features seen in the two bi-planar two-dimensional imagescan be determined by comparison to the three-dimensional CT image ormap.

Embodiments of the present invention may also be useful for verificationor validation following an interventional procedure. For example, in oneembodiment of the present invention, an interventional procedure may becompleted under fluoroscopic guidance, e.g. with two source-detectorpairs positioned at a minimum possible angle. A CT image may then beacquired by rotating the two source-detector pairs outward in oppositedirections from the minimum angle configuration. If thethree-dimensional image validates the success of the procedure, aphysician may proceed to remove any implements within the patient andclose incisions. If the three-dimensional image shows remainingmalignancy or other issues, the source-detector pairs may bere-positioned for real-time image guidance and the procedure continued.

FIG. 9 is a flowchart illustrating a number of manners in whichmodalities of an imaging apparatus may be utilized in a number ofembodiments of the present invention. As previously described, twosource-detector pairs can be utilized to acquire a CT data set. The samesource-detector pairs can then be positioned for fluoroscopy, e.g. at aminimum possible angle, or bi-planar imaging. If fluoroscopy is beingused as guidance for an interventional or surgical procedure, it may bevaluable to determine or confirm the locations and conditions ofinternal features being targeted by the procedure. The CT data set maybe utilized to determine absolute locations of internal features seen influoroscopic images, including third-dimension locations. It may also beused for registration of fluoroscopic images, e.g. to combine the viewstaken by two source-detector pairs in this embodiment. Similarly, a CTdata set can be used for registration of bi-planar images or as a priorfor reconstruction of a three-dimensional image, if the bi-planar imagesare tomosynthetic.

Embodiments of the present invention may utilize other combinations ofthe modalities of an apparatus comprising two source-detector pairs thatcan improve imaging speed, registration, or quality. Bi-planar imagingmay be performed before or after extended-FOV fluoroscopy, extended-FOVfluoroscopy before or after CT, CT before or after bi-planar imaging,and so forth, where acquisition of each type of image by a singleapparatus can allow for there to be little to no intermediate motionbetween a patient and the imaging.

The foregoing descriptions of specific embodiments of the presentinvention have been presented for purposes of illustration anddescription. They are not intended to be exhaustive or to limit theinvention to the precise forms disclosed, and many modifications andvariations are possible in light of the above teaching. The embodimentswere chosen and described in order to best explain the principles of theinvention and its practical application, to thereby enable othersskilled in the art to best utilize the invention and various embodimentswith various modifications as are suited to the particular usecontemplated. It is intended that the scope of the invention be definedby the claims appended hereto and their equivalents.

What is claimed is:
 1. A method of x-ray imaging comprising: rotating afirst X-ray source-detector pair through a first set of angles around anaxis of rotation; rotating a second X-ray source-detector pair through asecond set of angles around said axis of rotation, wherein said firstset of angles and said second set of angles do not overlap; acquiringimage data from said first X-ray source-detector pair and said secondX-ray source-detector pair during rotation; and storing said image datato form a computed imaging dataset.
 2. The method of claim 1 whereinsaid first set of angles and said second set of angles each comprise atleast 90 degrees.
 3. The method of claim 1 further comprising:completing rotation of the first X-ray source-detector pair through thefirst set of angles and the second X-ray source-detector pair throughthe second set of angles in less than 3 seconds.
 4. The method of claim1 further comprising: fixing positions of said first X-raysource-detector pair and said second X-ray source-detector pair at apredetermined angle of separation; and acquiring images from said firstX-ray source-detector pairs and said second X-ray source-detector pairwhile stationary.
 5. The method of claim 4 wherein said predeterminedangle of separation is a minimum angle.
 6. The method of claim 4 furthercomprising: utilizing said computed imaging dataset for registration ofsaid images.
 7. The method of claim 1 wherein source of said first X-raysource-detector pair is configured to emit radiation from a plurality ofdiscrete locations on its face.
 8. The method of claim 1 wherein sourceof said first X-ray source-detector pair is a point source.
 9. Themethod of claim 8 wherein source of said second X-ray source-detectorpair is configured to emit radiation from a plurality of discretelocations on its face.
 10. The method of claim 9 further comprising:rotating said first X-ray source-detector pair and said second-sourcedetector pair around a common axis of rotation through a sharedisocenter.
 11. The method of claim 1 further comprising: rotating saidfirst X-ray source-detector pair and said second-source detector pairaround a common axis of rotation through a shared isocenter.
 12. Themethod of claim 1 further comprising: imaging with a computed tomographymodality.
 13. The method of claim 12 further comprising: imaging with anextended field of view fluoroscopy modality.
 14. The method of claim 13further comprising: imaging with a bi-planar modality.
 15. A method ofx-ray imaging comprising: rotating two X-ray source-detector pairsaround an imaging volume, wherein at least one source of said X-raysource-detector pairs are configured to emit radiation from pluralitiesof discrete locations; acquiring a computed tomography dataset duringrotation of said two X-ray source-detector pairs; fixing said two X-raysource-detector pairs at a predetermined angle relative to one another;acquiring image data from said two X-ray source-detector pairs whilestationary at said predetermined angle relative to one another;reconstructing a three-dimensional image from said image data; andutilizing said computed tomography dataset as a prior for reconstructionof said three-dimensional image.
 16. The method of claim 15 wherein saidpredetermined angle is between 80 and 100 degrees, inclusive.
 17. Themethod of claim 15 further comprising: reconstructing saidthree-dimensional image using a maximum-likelihood expectationmaximization in voxel space.
 18. The method of claim 15 furthercomprising: reconstructing said three-dimensional image using anordered-subset expectation maximization framework.
 19. The method ofclaim 15 further comprising: reconstructing said three-dimensional imageusing a maximum likelihood algorithm for transmission tomography. 20.The method of claim 15 further comprising: correcting artifacts in saidthree-dimensional image using said computed tomography dataset.